Krasnow Institute > Monday Seminars > Abstracts

Pharmacogenomics of Cystic Fibrosis

Harvey B. Pollard, M.D., Ph.D.
Professor and Chair, Department of Anatomy, Physiology and Genetics, U.S.U. School of Medicine

Pharmacogenomics is the use of genomics in the service of drug discovery. Cystic Fibrosis, the most common fatal recessive genetic disease affecting the US population, provides an example of how the known genetic, biochemical and clinical aspects of the disease can be coupled to genomics for the purpose of developing gene-based surrogate endpoints for drug discovery and development. In principle, the bioinformatics algorithms developed for this well understood system can be extended by example to more complex disorders.

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