The Krasnow Institute for Advanced Study, of George Mason University

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Krasnow Institute > Monday Seminars > Abstracts

Estrogen and Synaptic Plasticity in the Hippocampus

Nancy Desmond

Department of Neurosurgery Univ. of Virginia Health System Charlottesville, VA

During much of a woman's life, circulating levels of estrogen and progesterone are changing, both day to day and across the life span. These hormonal fluctuations influence more than just reproductive function, including perceptual and cognitive abilities. One brain region that plays an important role in cognition is the hippocampus. The hypothesis underlying my research program is that the hippocampus shifts its optimal computational functions as ovarian steroid levels naturally vary across the menstrual/estrous cycle. Today I will discuss ovarian steroid-dependent plasticity of hippocampal structure and function.

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