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Olfactory coding in the behaving mouse

Dima Rinberg

Monell Chemical Senses Center

The olfactory bulb is the first stage of olfactory information processing. It receives inputs from olfactory receptors and sends output to multiple brain areas. The vast majority of our knowledge about the function of mammalian olfactory system was obtained in anesthetized preparations. Recordings from mitral cells in the olfactory bulb in behaving animals suggest that neuronal dynamics is quite different in behaving as compared to anesthetized animals. While spontaneous activity of these cells is much higher, the odor responses are much sparser and weaker in the awake animal. The critical features of the neuronal code carrying information about olfactory stimuli are still unknown. Current experiments in awake behaving mice involved in odor guided behavior yield some clues about the nature of
the olfactory code.

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