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Krasnow Institute > Monday Seminars > Abstracts Informatics and the Origin of Metabolism Harold Morowitz From the perspectives of complexity and emergence the first step of biogenesis is to see the emergence of the core of the metabolic chart from the relevant atoms. Thus the agents are atoms of C, H, N, O, P, S, Fe, Ni, etc. and emergent structures are the core molecules of metabolism, the citric acid cycle. The interaction rules are the reactions of organic chemistry, which at the core is organic chemistry. To approach the problem, we need the data base of Beilstein that includes 3.5 million organic molecules. By applying physically based processing rules to Beilstein we select a set of 147 chemicals which contain the 11 intermediates of the reductive citric acid cycle.
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