CA3 Pyramidal Cells (CA3 pc)

Main references (data with "?" refer to a reasonable guess; with "??" to a total guess):
Morphology: Larkman, 1991; Van Pelt et al., 1997.
Number and connectivity: Bernard and Wheal, 1994; Amaral et al., 1990.
Biochemistry and physiology: Traub et al., 1994; Spruston et al., 1995.

Type: Principal cells, excitatory (glutamate).
Number: 200,000
Location (CA3): Soma in pyramidal layer, basal dendrites in oriens, apical dendrites in radiatum, axons (Shaffer collaterals) start in oriens and cross into radiatum.

Explicit morphological data: Southampton archive (cells 148-160)

Notes: PP (EC) LTP is NMDA-dependent, MF (DG gc) LTP is not (see for instance Yeckel and Berger, 1998).
 

Connectivity:

Axonal output (number of cells contacted, with one synapse unless specified; in parenthesis: number of cells of that type):
18,000 CA1 pc x5 (300,000)
60 CA1 cc (1000)
240 CA1 bc (4000)
240 CA1 oa (4000)
240 CA1 lm (4000)
4000 CA3 pc (200,000)
400 CA3 ri (4000)
400 CA3 oi (4000)
100 CA3 cc (1000)

Axo-somatic input:
GABA 290 CA3 cc x20 on axon and soma

Apical Dendritic input:
Glu ?? EC (200,000) on distal spines (perforant path)
Glu ?? DG gc (1,000,000) on proximal spines and? shaft? (mossy fibers)
Glu 2000 CA3 pc (200,000) on spines
GABA 2400 CA3 ri (4000) on shaft
AcCh ?? SHP on spines?

Basal Dendritic input:
Glu 2000 CA3 pc (200,000) on spines
GABA 2400 CA3 oi (4000) on shaft
AcCh ?? SHP on spines?

Biochemistry:
 
Distal apical Spines: NMDA, AMPA, mGlu, ER, ?
Other spines: AMPA, mAcCh, ER, ?
Dendrites: GABA-A?, GABA-B, CCa?, Esp, EC, EP
Soma: GABA-A, GABA-B, CNa, CK?, AMPA?, NMDA?, ED
Axon: GABA-A, GABA-B, EP,EC, CNa, CK?
 

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