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NEUR 602
CELLULAR NEUROSCIENCE

Fall 2009
Tues, 1:30 - 4:20 pm
Krasnow Institute Lecture Hall (Room 228)

Instructor: Dr. Kim L. Blackwell
Office Location: Krasnow Institute, Room 105
Office Hours: Tues 4:30 - 5:30 pm or by appointment

COURSE DESCRIPTION

An intense overview of cellular neuroscience for graduate students interested in studying how nerve cells integrate and transmit signals, and how behavior emerges from the integrated actions of populations or circuits of nerve cells. The course covers electrical and biochemical properties of single neurons, and electrical and chemical communication between neurons.

SYLLABUS

WEEK/DATE TOPIC READING
1
09/01		 Introduction, Glia, Morphology; Intro, lecture MN Chap 1
2
09/8		 Subcellular organization; lecture MN Chap 2, Paper
3
09/15		 Resting potential and Ion pumps; Lecture MN Chap 5 (pp 134-139), LK Chap 3 Homework
4
9/22		 Ionic Channels; lecture MN Chap 6 (pp159-180), LK Chap 4,5; Homework
5
9/29		 Action Potentials; lecture MN Chap 5 (pp 139-155), Chap 7 (pp 181-188), LK Chapter 6 paper
6
10/06		 Electrotonic properties, Review; lecture MN Chap 4 homework
7
10/20		 MIDTERM (Week 1-6 lectures)
8
10/27		 Synthesis of Neurotransmitters; lectureMN Chapter 9, LK Chap 8,10 paper
9
11/03		 Transmitter release; lecture MN Chapter 8, LK Chap 9 homework1, homework2
10
11/10 		Ionotropic receptors, Postsynaptic potentials; lecture MN Chapter 11 (pp321-343), 16(469-481); LK Chap 8, 11 paper
11
11/17		 Gap junctions, Signal Propagation and Integration; lecture MN Chap 15 (445-454), 16 (482-487), 17; homework
12
11/24		 Metabotropic receptors, Neuromodulutors and second messengers; lecture MN Chapter 11 (pp343-355), 12, LK Chap 12,13 paper
13
12/01		 Non classical neurotransmitters; regulation of gene expression; lecture MN Chap 10 (pp 301-320), 13 (pp 391-412) paper
14
12/08		 Learning and Synaptic Plasticity; lecture MN Chap 19 (pp 539-561, 576-591)
12/15 FINAL, 1:30 pm - 4:20 PM (Lectures weeks 8-14)


TEXT

MN (required): Byrne and Roberts From Molecules to Network, 2nd ed. Academic Press, 2009

LK (recommended): Levitan and Kaczmarek, The Neuron: Cell and Molecular Biology,3rd Edition Oxford University Press, 2002