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Krasnow Institute > Monday Seminars > Abstracts Functional Neuroanatomy Brian Knutson Activation of ventral forebrain areas has been observed in monkeys anticipating rewards. We sought to visualize the activity of this circuitry in humans anticipating monetary reward and punishment with fMRI. 12 right-handed males participated in 10-minute approach and active avoidance tasks in counterbalanced order. During each task, MR volumes depicting BOLD-contrast were acquired. Results reveal activation of circuitry running from the medial dorsal thalamus through the anterior cingulate and mesial prefrontal cortex during anticipation of both reward and punishment. Across subjects, activation of these medial forebrain areas was not correlated with motor response, but was correlated with personality variables related to incentive sensitivity. Our findings centrally implicate medial forebrain areas in the anticipation of reward and punishment. -
The Krasnow Institute for Advanced Study |
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