|
  |
|
|
Krasnow Institute > Monday Seminars > Abstracts Magnetic Resonance Imaging Microscopy: An Innovative Approach for Monitoring Neuropathology David S. Lester, Ph.D. Preclinical neurotoxicology evaluations are made using standard behavioral testing along with neurohistological analysis of 1-3 coronal sections stained by a single procedure. This approach has been used for decades. With the advent of new imaging technologies, there are new opportunities for changing the way that histopathology has been done. Magnetic Resonance Imaging (MRI) has the advantages that it is noninvasive or nondestructive and visualizes tissues or organisms in three dimensions. An extension of human MRI, MRI microscopy (MRM), provides the opportunity of determining pathologies in tissues at resolutions in the tens of microns. This approach has been applied and tested on a number of brain tissue samples from established animal models of toxicity in order to determine the ability of this approach to detect pathologies of the brain. MRM was successful in detecting a variety of different neuronal lesions and provided perspectives and insights that were not available using standard histological approaches. This method provides an excellent tool for a rapid and sensitive noninvasive screen of tissue for identification of potential pathologies.
The Krasnow Institute for Advanced Study |
|
